Laura D Brown Selected Research

Placental Insufficiency

1/2022	Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency.
1/2021	Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth.
1/2020	Reduced Na+ K+ -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity.
11/2019	Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb.
12/2018	Prolonged amino acid infusion into intrauterine growth-restricted fetal sheep increases leucine oxidation rates.
11/2018	IUGR impairs cardiomyocyte growth and maturation in fetal sheep.
1/2018	Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep.
1/2017	Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro.
10/2016	Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep.
1/2016	Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction.

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Laura D Brown Research Topics

Disease

18	Placental Insufficiency 01/2022 - 07/2009
15	Fetal Growth Retardation (Intrauterine Growth Retardation) 01/2022 - 01/2009
10	Hypoxia (Hypoxemia) 01/2022 - 01/2009
7	Hypoglycemia (Reactive Hypoglycemia) 02/2015 - 12/2006
6	Hyperinsulinism (Hyperinsulinemia) 10/2020 - 12/2006
4	Insulin Resistance 01/2016 - 05/2011
3	Fetal Weight 01/2021 - 01/2021
2	Necrotizing Enterocolitis 12/2014 - 01/2014
2	Acidosis 09/2009 - 01/2009
1	Hypertrophy 01/2021
1	Patent Ductus Arteriosus 10/2018
1	Lung Diseases (Lung Disease) 12/2014
1	Sepsis (Septicemia) 12/2014
1	Malnutrition (Nutritional Deficiencies) 01/2013
1	Birth Weight (Birth Weights) 06/2012
1	Type 2 Diabetes Mellitus (MODY) 05/2011
1	Obesity 05/2011
1	Fetal Hypoxia 09/2009

Drug/Important Bio-Agent (IBA)

21	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 12/2006
18	Insulin (Novolin)FDA Link 01/2022 - 12/2006
14	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2009
11	Amino Acids FDA Link 01/2022 - 12/2006
6	Oxygen (Dioxygen)IBA 01/2022 - 10/2015
4	Lactic Acid (Lactate)FDA LinkGeneric 01/2022 - 02/2015
4	Glucagon (Glukagon)FDA Link 01/2021 - 02/2008
3	Pyruvic Acid (Pyruvate)IBA 01/2022 - 02/2015
3	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2022 - 02/2008
3	Hormones (Hormone)IBA 01/2021 - 01/2017
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2022 - 01/2016
2	Leucine (L-Leucine)FDA Link 01/2021 - 12/2006
2	Muscle Proteins (Muscle Protein)IBA 11/2019 - 01/2018
2	Messenger RNA (mRNA)IBA 01/2016 - 02/2008
2	CarbohydratesIBA 01/2014 - 01/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2021
1	CarbonIBA 10/2020
1	4- chloro- 3',6'- dimethyl- 2,2'- iminodibenzoate (TO 115)IBA 11/2018
1	Indomethacin (Indometacin)FDA LinkGeneric 10/2018
1	Acetaminophen (Paracetamol)FDA LinkGeneric 10/2018
1	Ibuprofen (Motrin)FDA LinkGeneric 10/2018
1	MicronutrientsIBA 12/2014
1	UbiquitinIBA 06/2014
1	Ligases (Synthetase)IBA 06/2014
1	Phosphotransferases (Kinase)IBA 01/2013
1	Dietary ProteinsIBA 01/2011
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 12/2009
1	TOR Serine-Threonine KinasesIBA 12/2009
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 12/2009
1	Essential Amino AcidsIBA 09/2009
1	RNA (Ribonucleic Acid)IBA 07/2009
1	Hypoglycemic Agents (Hypoglycemics)IBA 04/2009
1	Lysine (L-Lysine)FDA Link 04/2009
1	Transcription Factors (Transcription Factor)IBA 02/2008
1	Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA 02/2008
1	PhosphoenolpyruvateIBA 02/2008
1	EnzymesIBA 02/2008
1	Liver GlycogenIBA 02/2008

Therapy/Procedure

1	Compressed Air 01/2019
1	Catheters 01/2018